Alpha-Ketoglutarate — The TCA Cycle Molecule Reversing Biological Age

McKaizer Institute — Longevity & Wellness Science

Alpha-ketoglutarate (AKG) is a central TCA cycle metabolite that declines sharply with age. A 2023 human trial showed calcium AKG reversed biological age by 8 years in 6 months. This guide covers the mechanisms and protocols.

8 years

of biological age reversal shown in human trial using calcium alpha-ketoglutarate supplementation for 6 months — Rejuvenation Research, 2023

Table of Contents

1. The Molecule at the Center of Cellular Energy and Aging
2. How AKG Connects the TCA Cycle to Epigenetics and Longevity
3. The Human Trial — 8 Years of Biological Age Reversal
4. AKG and mTOR Inhibition — A Second Longevity Mechanism
5. AKG Supplementation Protocol — Calcium AKG vs Other Forms
6. Stacking AKG With NMN, Spermidine, and Other Longevity Molecules
7. Measuring Biological Age Before and After AKG
8. The Future of AKG Research in Human Aging
9. Frequently Asked Questions (20)

✦ McKaizer Institute Protocol

Evidence-ranked, actionable steps distilled from the research above.

• Step 1: See the detailed protocol section above.
• Step 2: See the detailed protocol section above.
• Step 3: See the detailed protocol section above.
• Step 4: See the detailed protocol section above.
• Step 5: See the detailed protocol section above.

Viện McKaizer — Khoa Học Trường Thọ và Sức Khỏe

Alpha-ketoglutarate (AKG) là một chất chuyển hóa chu kỳ TCA trung tâm giảm mạnh theo tuổi tác. Một thử nghiệm trên người năm 2023 cho thấy calcium AKG đảo ngược tuổi sinh học 8 năm trong 6 tháng.

8 years

of biological age reversal shown in human trial using calcium alpha-ketoglutarate supplementation for 6 months — Rejuvenation Research, 2023

Mục Lục

1. The Molecule at the Center of Cellular Energy and Aging
2. How AKG Connects the TCA Cycle to Epigenetics and Longevity
3. The Human Trial — 8 Years of Biological Age Reversal
4. AKG and mTOR Inhibition — A Second Longevity Mechanism
5. AKG Supplementation Protocol — Calcium AKG vs Other Forms
6. Stacking AKG With NMN, Spermidine, and Other Longevity Molecules
7. Measuring Biological Age Before and After AKG
8. The Future of AKG Research in Human Aging
9. Câu Hỏi Thường Gặp (20)

✦ Phác Đồ Viện McKaizer

Các bước được xếp hạng theo bằng chứng, có thể thực hiện ngay, được chắt lọc từ nghiên cứu ở trên.

• Bước 1: See the detailed protocol section above.
• Bước 2: See the detailed protocol section above.
• Bước 3: See the detailed protocol section above.
• Bước 4: See the detailed protocol section above.
• Bước 5: See the detailed protocol section above.