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McKaizer Institute — Longevity & Wellness Science
Ergothioneine — found primarily in mushrooms — has its own dedicated cellular transporter (OCTN1), suggesting it is essential for life. Population studies link high ergothioneine intake to dramatic reductions in cardiovascular disease, dementia, and all-cause mortality.
68%
lower risk of mild cognitive impairment in individuals with the highest blood ergothioneine levels — Singapore National Health Study, 2023
Table of Contents
- The Longevity Vitamin You Have Never Heard Of
- How Ergothioneine Works — Mitochondrial Protection and Antioxidant Power
- The Epidemiological Evidence — Cognition, Cardiovascular and Mortality
- Food Sources — Mushrooms as a Longevity Superfood Reconsidered
- Supplementation — Does It Deliver What Diet Cannot?
- Stacking Ergothioneine With Spermidine and Urolithin A
- Measuring Ergothioneine Status
- The Future of Ergothioneine Research
- Frequently Asked Questions (20)
The Longevity Vitamin You Have Never Heard Of

How Ergothioneine Works — Mitochondrial Protection and Antioxidant Power

“Ergothioneine fits the criteria for a longevity vitamin — its dedicated transporter implies essentiality, and the epidemiological data on cognitive protection is among the strongest I have seen.”
The Epidemiological Evidence — Cognition, Cardiovascular and Mortality

Food Sources — Mushrooms as a Longevity Superfood Reconsidered

Supplementation — Does It Deliver What Diet Cannot?

Stacking Ergothioneine With Spermidine and Urolithin A

Measuring Ergothioneine Status

The Future of Ergothioneine Research

✦ McKaizer Institute Protocol
Evidence-ranked, actionable steps distilled from the research above.
- Step 1: See the detailed protocol section above.
- Step 2: See the detailed protocol section above.
- Step 3: See the detailed protocol section above.
- Step 4: See the detailed protocol section above.
- Step 5: See the detailed protocol section above.









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