Rapamycin and mTOR — The Most Promising Longevity Drug in History

McKaizer Institute — Longevity & Wellness Science

Rapamycin extends lifespan in every animal model tested and is now in human trials. This guide covers the mTOR pathway, rapamycin protocols, risk-benefit analysis, and what the PEARL trial is revealing about longevity in humans.

60%

increase in median lifespan in mice treated with rapamycin — the most replicated longevity result in laboratory aging science

Table of Contents

1. mTOR — The Master Switch Between Growth and Longevity
2. Rapamycin’s Lifespan Extension — From Yeast to Mammals
3. How Rapamycin Works at the Molecular Level
4. Human Trials — The PEARL Study and What It Shows
5. Rapamycin Protocols — Dosing, Cycling, and Risks
6. Alternatives to Rapamycin — Berberine, Acarbose, Torin
7. Monitoring mTOR Inhibition — Biomarkers to Track
8. The Future of mTOR-Targeted Longevity Medicine
9. Frequently Asked Questions (20)

✦ McKaizer Institute Protocol

Evidence-ranked, actionable steps distilled from the research above.

• Step 1: See the detailed protocol section above.
• Step 2: See the detailed protocol section above.
• Step 3: See the detailed protocol section above.
• Step 4: See the detailed protocol section above.
• Step 5: See the detailed protocol section above.

Viện McKaizer — Khoa Học Trường Thọ và Sức Khỏe

Rapamycin kéo dài tuổi thọ trong mọi mô hình động vật được thử nghiệm và hiện đang trong các thử nghiệm trên người. Hướng dẫn này đề cập đến con đường mTOR, các giao thức rapamycin, phân tích rủi ro-lợi ích và những gì thử nghiệm PEARL đang tiết lộ.

60%

increase in median lifespan in mice treated with rapamycin — the most replicated longevity result in laboratory aging science

Mục Lục

1. mTOR — The Master Switch Between Growth and Longevity
2. Rapamycin’s Lifespan Extension — From Yeast to Mammals
3. How Rapamycin Works at the Molecular Level
4. Human Trials — The PEARL Study and What It Shows
5. Rapamycin Protocols — Dosing, Cycling, and Risks
6. Alternatives to Rapamycin — Berberine, Acarbose, Torin
7. Monitoring mTOR Inhibition — Biomarkers to Track
8. The Future of mTOR-Targeted Longevity Medicine
9. Câu Hỏi Thường Gặp (20)

✦ Phác Đồ Viện McKaizer

Các bước được xếp hạng theo bằng chứng, có thể thực hiện ngay, được chắt lọc từ nghiên cứu ở trên.

• Bước 1: See the detailed protocol section above.
• Bước 2: See the detailed protocol section above.
• Bước 3: See the detailed protocol section above.
• Bước 4: See the detailed protocol section above.
• Bước 5: See the detailed protocol section above.