McKaizer Institute — Longevity & Wellness
Partial epigenetic reprogramming is the most exciting frontier in longevity science. Learn how Yamanaka factors, DNA methylation clocks, and lifestyle choices rewrite your aging program.
3.23 years
of biological age reversal achieved in 8 weeks through diet, exercise, sleep, and stress reduction — Dain et al., Aging journal 2021
Table of Contents
- Your Epigenome: The Software of Aging That Can Be Rewritten
- DNA Methylation Clocks: Measuring Your True Biological Age
- The Yamanaka Factors and Partial Reprogramming
- David Sinclair’s Information Theory of Aging
- Lifestyle Epigenetics: How Your Daily Choices Rewrite Your DNA
- Epigenetic Testing: What the Clocks Actually Measure
- The Companies Racing to Commercialize Reprogramming
- The Near Future: Clinical Reprogramming by 2030
Your Epigenome: The Software of Aging That Can Be Rewritten
[Section ‘Your Epigenome: The Software of Aging That Can Be Rewritten’ could not be generated]
DNA Methylation Clocks: Measuring Your True Biological Age
[Section ‘DNA Methylation Clocks: Measuring Your True Biological Age’ could not be generated]
“We can now read the biological age from a blood sample and begin to understand how to reverse it. This changes everything about how we approach medicine.”
The Yamanaka Factors and Partial Reprogramming
[Section ‘The Yamanaka Factors and Partial Reprogramming’ could not be generated]
David Sinclair’s Information Theory of Aging
[Section ‘David Sinclair’s Information Theory of Aging’ could not be generated]
Lifestyle Epigenetics: How Your Daily Choices Rewrite Your DNA
[Section ‘Lifestyle Epigenetics: How Your Daily Choices Rewrite Your DNA’ could not be generated]
Epigenetic Testing: What the Clocks Actually Measure
[Section ‘Epigenetic Testing: What the Clocks Actually Measure’ could not be generated]
The Companies Racing to Commercialize Reprogramming
[Section ‘The Companies Racing to Commercialize Reprogramming’ could not be generated]
The Near Future: Clinical Reprogramming by 2030
[Section ‘The Near Future: Clinical Reprogramming by 2030’ could not be generated]
Frequently Asked Questions
What is epigenetic reprogramming?
Epigenetic reprogramming uses Yamanaka transcription factors (OCT4, SOX2, KLF4, cMYC) to reset the epigenetic marks on DNA — essentially rebooting a cell’s biological age without changing the genetic sequence. Partial reprogramming (using OSK factors) reverses aging markers without dedifferentiation, as demonstrated in Sinclair Lab’s vision restoration study.
What is a DNA methylation clock?
DNA methylation clocks (Horvath clock, DunedinPACE, GrimAge) measure biological age by analyzing methylation patterns at specific CpG sites across the genome. DunedinPACE measures the pace of aging (how fast you’re aging), while TruAge measures your current biological age. These are the most validated biological age tests available.
Can lifestyle changes reverse epigenetic aging?
Yes. The Fahy et al. 2019 TRIIM trial reversed epigenetic age by 2.5 years in 9 men using GH, DHEA, and metformin. The Dain et al. study reversed biological age by 3.23 years using diet, sleep, exercise, and relaxation. Exercise, fasting, and stress reduction consistently show 1-3 year biological age reversal in controlled studies.
McKaizer Institute — Longevity & Wellness
Partial epigenetic reprogramming is the most exciting frontier in longevity science. Learn how Yamanaka factors, DNA methylation clocks, and lifestyle choices rewrite your aging program.
3.23 years
of biological age reversal achieved in 8 weeks through diet, exercise, sleep, and stress reduction — Dain et al., Aging journal 2021
Table of Contents
- Your Epigenome: The Software of Aging That Can Be Rewritten
- DNA Methylation Clocks: Measuring Your True Biological Age
- The Yamanaka Factors and Partial Reprogramming
- David Sinclair’s Information Theory of Aging
- Lifestyle Epigenetics: How Your Daily Choices Rewrite Your DNA
- Epigenetic Testing: What the Clocks Actually Measure
- The Companies Racing to Commercialize Reprogramming
- The Near Future: Clinical Reprogramming by 2030
Your Epigenome: The Software of Aging That Can Be Rewritten
[Section ‘Your Epigenome: The Software of Aging That Can Be Rewritten’ could not be generated]
DNA Methylation Clocks: Measuring Your True Biological Age
[Section ‘DNA Methylation Clocks: Measuring Your True Biological Age’ could not be generated]
“We can now read the biological age from a blood sample and begin to understand how to reverse it. This changes everything about how we approach medicine.”
The Yamanaka Factors and Partial Reprogramming
[Section ‘The Yamanaka Factors and Partial Reprogramming’ could not be generated]
David Sinclair’s Information Theory of Aging
[Section ‘David Sinclair’s Information Theory of Aging’ could not be generated]
Lifestyle Epigenetics: How Your Daily Choices Rewrite Your DNA
[Section ‘Lifestyle Epigenetics: How Your Daily Choices Rewrite Your DNA’ could not be generated]
Epigenetic Testing: What the Clocks Actually Measure
[Section ‘Epigenetic Testing: What the Clocks Actually Measure’ could not be generated]
The Companies Racing to Commercialize Reprogramming
[Section ‘The Companies Racing to Commercialize Reprogramming’ could not be generated]
The Near Future: Clinical Reprogramming by 2030
[Section ‘The Near Future: Clinical Reprogramming by 2030’ could not be generated]
Frequently Asked Questions
What is epigenetic reprogramming?
Epigenetic reprogramming uses Yamanaka transcription factors (OCT4, SOX2, KLF4, cMYC) to reset the epigenetic marks on DNA — essentially rebooting a cell’s biological age without changing the genetic sequence. Partial reprogramming (using OSK factors) reverses aging markers without dedifferentiation, as demonstrated in Sinclair Lab’s vision restoration study.
What is a DNA methylation clock?
DNA methylation clocks (Horvath clock, DunedinPACE, GrimAge) measure biological age by analyzing methylation patterns at specific CpG sites across the genome. DunedinPACE measures the pace of aging (how fast you’re aging), while TruAge measures your current biological age. These are the most validated biological age tests available.
Can lifestyle changes reverse epigenetic aging?
Yes. The Fahy et al. 2019 TRIIM trial reversed epigenetic age by 2.5 years in 9 men using GH, DHEA, and metformin. The Dain et al. study reversed biological age by 3.23 years using diet, sleep, exercise, and relaxation. Exercise, fasting, and stress reduction consistently show 1-3 year biological age reversal in controlled studies.
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